Impact of nitric oxide synthesis modulators on the state of humoral immune system in experimental antiphospholipid syndrome

Background : Antiphospholipid syndrome is an autoimmune disease of multiple venous and/or arterial thrombosis pregnancy loss. Oxidative stress only enhances the body’s immune response. In pathological conditions, formation nitric oxide disrupted, which can be manifested by vasoconstriction, increased coagulation, and endothelial dysfunction. Objective The aim research was to study level immunoglobulins circulating complexes (CICs) in experimental antiphospholipid its correction with L-arginine aminoguanidine. Materials methods modeled on white female BALB/c mice. (25 mg/kg) aminoguanidine (10 were used for correction. content CICs studied. Results It established that (Ig) group animals compare control. levels IgA decreased significantly, IgM IgG did not change mice cases administration, no significant decrease evidenced syndrome. using a combination agents, change, all other parameters APS. Conclusion humoral immunity increase. depending chosen agents or their complex administration. Thus, has positive effect various responses decreasing negative impact pathobiochemical alterations.